The FAME 3 subgroup analysis demonstrated that in patients with three-vessel coronary artery disease, women had a higher 3-year risk of major adverse cardiac and cerebrovascular events (MACCE; all-cause death, myocardial infarction [MI], stroke, and repeat revascularization) after coronary artery bypass grafting (CABG) than men. In women, there was no difference in 3-year MACCE risk between those who underwent fractional flow reserve (FFR)-guided PCI and those who underwent CABG, whereas in men, outcomes were better with CABG, Dr. Kuniaki Takahashi and colleagues, Stanford University, USA, reported in the January 27 issue of JACC: Cardiovascular Interventions.