The MITO registry demonstrated that in percutaneous coronary intervention (PCI) for unprotected left main (LM) true bifurcation lesions, patients with smaller change in bifurcation angle between diastole and systole had a significantly lower rate of target lesion failure (TLF; cardiac death, TLR and MI) with a two-stent strategy compared to a provisional single stenting strategy. In contrast, patients with larger change in bifurcation angle had a significantly higher TLF rate with the two-stent strategy, Dr. Yusuke Watanabe and colleagues, New Tokyo Hospital, Japan, reported in the December issue of Catheterization & Cardiovascular Interventions.