AstraZeneca Announces Discontinuation of STABILIZE-CKD and DIALIZE-Outcomes Phase III Trials

AstraZeneca Announces Discontinuation of STABILIZE-CKD and DIALIZE-Outcomes Phase III Trials

December 1, 2023: AstraZeneca announced that it has decided to discontinue the STABILIZE-CKD trial and the DIALIZE-Outcomes Phase III trial that evaluate zirconium cyclosilicate sodium hydrate (product name: Lokelma) due to delays in patient enrollment and low event rates. The two studies were designed to evaluate the effects of the drug on the cardiac and renal systems.

Both studies were part of the CRYSTALIZE evidence program that evaluates the potential benefits of L...
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