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IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Disease: The OPTIMAL Trial

The OPTIMAL trial demonstrated that among patients with unprotected left main (LM) disease, IVUS-guided PCI did not reduce the risk of a patient-oriented composite endpoint of all-cause death, stroke, MI, and revascularization compared with angiography-guided PCI over a median follow-up of 2.9 years, according to a study presented by Dr. Luca Testa, San Raffaele Hospital, Italy, in the Late-Breaking Clinical Trials session at ACC.26.

In the OPTIMAL trial, 806 patients with unprotected LM disease and angiographic stenosis ≥50%, wh...

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