Treatment effect of DOAC vs. warfarin by degree of renal dysfunction: a network meta-analysis

Treatment effect of DOAC vs. warfarin by degree of renal dysfunction: a network meta-analysis

A patient-level network meta-analysis of the COMBINE AF database found that standard-dose direct oral anticoagulants (DOACs) are safer and more effective than warfarin in patients with creatinine clearance (CrCl) values ≥25 mL/min. Dr. Josephine Harrington, Duke University, USA, and colleagues reported in the June 6 issue of Circulation.

Dr. Harrington and colleagues conducted a network meta-analysis of patient-level data using the COMB...
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