DOAC Monotherapy vs Combination Therapy With Clopidogrel in Patients With Atrial Fibrillation Beyond 1 Year After DES Implantation: The ADAPT AF-DES Trial

DOAC Monotherapy vs Combination Therapy With Clopidogrel in Patients With Atrial Fibrillation Beyond 1 Year After DES Implantation: The ADAPT AF-DES Trial

The ADAPT AF-DES trial demonstrated that among patients with atrial fibrillation (AF) more than 1 year after DES implantation, antithrombotic therapy with direct oral anticoagulant (DOAC) monotherapy was noninferior to DOAC plus clopidogrel combination therapy with respect to 12-month net adverse clinical events (NACE), Dr. Seung-Jun Lee and colleagues, Yonsei University College of Medicine, in the February 12 issue of The New England Journal of Medicine.

The researchers evaluated 960 patients with AF who had undergone coronary DES implantation more than...
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