Impact of Delayed Referral on Clinical Outcomes in Patients with CLTI: The COMET Study

Impact of Delayed Referral on Clinical Outcomes in Patients with CLTI: The COMET Study

The COMET study demonstrated that among patients with chronic limb-threatening ischemia (CLTI) and Rutherford class 5/6, delayed referral to a facility capable of performing revascularization after wound onset was associated with prolonged time to wound healing, lower wound healing rates, and reduced amputation-free survival, according to a study presented by Dr. Shunsuke Kojima, Tokyo Bay Urayasu Ichikawa Medical Center, Japan, in the Late Breaking Clinical Trial session at CVIT 2025.

In the COMET study, 815 patients with Rutherford class 5/6 CLTI, enrolled retrospectively from eight...
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